There are many trains that connect Santander and Madrid, with an average travel duration of 4:40 hours, operated by Spanish company RENFE (phone: Santander (+34) 942 280202 and Madrid (+34) 91 3289020). For more information visit www.renfe.es

From Madrid's airport use the bus, metro or taxi to go to Madrid-Chamartin train station. There are bus lines that connect the airport to the Plaza de Colon. From there to the train station there are different possibilities: buses, subways, taxis. 

All trains arrive at the same train station at Santander, in the center of the city. Once there, use the urban bus service to arrive ACORDE, at 100 meters distance, or the Santander taxis service (phone: (+34) 942 33 33 33).